We report on absolute proper-motion measurements of an H _ { 2 } O maser source in the NGC 281 West molecular cloud , which is located \sim 320 pc above the Galactic plane and is associated with an H \emissiontype I loop extending from the Galactic plane .
We have conducted multi-epoch phase-referencing observations of the maser source with VERA ( VLBI Exploration of Radio Astrometry ) over a monitoring period of 6 months since May 2006 .
We find that the H _ { 2 } O maser features in NGC 281 West are systematically moving toward the southwest and further away from the Galactic plane with a vertical velocity of \sim 20 - 30 km s ^ { -1 } at its estimated distance of 2.2 - 3.5 kpc .
Our new results provide the most direct evidence that the gas in the NGC 281 region on the H \emissiontype I loop was blown out from the Galactic plane , most likely in a superbubble driven by multiple or sequential supernova explosions in the Galactic plane .