The XENON10 experiment at the Gran Sasso National Laboratory uses a 15 kg xenon dual phase time projection chamber ( XeTPC ) to search for dark matter weakly interacting massive particles ( WIMPs ) . The detector measures simultaneously the scintillation and the ionization produced by radiation in pure liquid xenon , to discriminate signal from background down to 4.5 keV nuclear recoil energy . A blind analysis of 58.6 live days of data , acquired between October 6 , 2006 and February 14 , 2007 , and using a fiducial mass of 5.4 kg , excludes previously unexplored parameter space , setting a new 90 % C.L . upper limit for the WIMP-nucleon spin-independent cross-section of 8.8 \times 10 ^ { -44 } cm ^ { 2 } for a WIMP mass of 100 GeV/ c ^ { 2 } , and 4.5 \times 10 ^ { -44 } cm ^ { 2 } for a WIMP mass of 30 GeV/ c ^ { 2 } . This result further constrains predictions of supersymmetric models .