We study the statistical properties of the cosmological 21 cm signal from both the intergalactic medium ( IGM ) and minihalos , using a reionization simulation that includes a self–consistent treatment of minihalo photoevaporation . We consider two models for minihalo formation and three typical thermal states of the IGM – heating purely by ionization , heating from both ionizing and Ly \alpha photons , and a maximal ” strong heating ” model . We find that the signal from the IGM is almost always dominant over that from minihalos . In our calculation , the differential brightness temperature , { \delta } T _ { b } , of minihalos is never larger than 2 mK . Although there are indeed some differences in the signals from the minihalos and from the IGM , even with the planned generation of radio telescopes it will be unfeasible to detect them . However , minihalos significantly affect the ionization state of the IGM and the corresponding 21 cm flux .