We present new multi-configuration VLA H I spectral line observations of the M81 group drr post-starburst galaxy DDO 165 . The H I morphology is complex , with multiple column density peaks surrounding a large region of very low H I surface density that is offset from the center of the stellar distribution . The bulk of the neutral gas is associated with the southern section of the galaxy ; a secondary peak in the north contains \sim 15 % of the total H I mass . These components appear to be kinematically distinct , suggesting that either tidal processes or large-scale blowout have recently shaped the ISM of DDO 165 . Using spatially-resolved position-velocity maps , we find multiple localized high-velocity gas features . Cross-correlating with radius-velocity analyses , we identify eight shell/hole structures in the ISM with a range of sizes ( \sim 400–900 pc ) and expansion velocities ( \sim 7–11 km s ^ { -1 } ) . These structures are compared with narrow- and broad-band imaging from KPNO and HST . Using the latter data , recent works have shown that DDO 165 ’ s previous “ burst ” phase was extended temporally ( > \sim 1 Gyr ) . We thus interpret the high-velocity gas features , H I holes , and kinematically distinct components of the galaxy in the context of the immediate effects of “ feedback ” from recent star formation . In addition to creating H I holes and shells , extended star formation events are capable of creating localized high velocity motion of the surrounding interstellar material . A companion paper connects the energetics from the H I and HST data .