We report constraints on spin-independent weakly interacting massive particle ( WIMP ) -nucleon scattering using a 3.35 \times 10 ^ { 4 } kg day exposure of the Large Underground Xenon ( LUX ) experiment . A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead , South Dakota ( USA ) . With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results , this search yields no evidence of WIMP nuclear recoils . At a WIMP mass of 50 GeV c ^ { -2 } , WIMP-nucleon spin-independent cross sections above 2.2 \times 10 ^ { -46 } cm ^ { 2 } are excluded at the 90 % confidence level . When combined with the previously reported LUX exposure , this exclusion strengthens to 1.1 \times 10 ^ { -46 } cm ^ { 2 } at 50 GeV c ^ { -2 } .