The installation of forward detectors in CMS and ATLAS turn the LHC to an effective photon-photon collider . The elastic scattering of the beam-protons via the emission of photons , which can be identified by tagging the intact protons in the forward detectors , provides a powerful diagnostic of the central production of new particles through photon-photon annihilation . In this letter we study the central production of dark matter particles and the potential of LHC to constrain the cross section of this process . By virtue of the crossing symmetry , this limit can immediately be used to constrain the production of monochromatic gamma-rays in dark matter annihilation , a smoking gun signal under investigation in indirect dark matter searches . We show that with the integrated luminosity \mathcal { L } = 30 ~ { } { fb } ^ { -1 } in LHC at center-of-mass energy \sqrt { s } = 13 TeV , for dark matter masses \sim ( 50 - 600 ) GeV , a model-independent constraint on the cross section of dark matter annihilation to monochromatic gamma-rays at the same order of magnitude as the current Fermi-LAT and the future limits from CTA , can be obtained .