The globular cluster Omega Centauri is the most massive and luminous cluster in the Galaxy . The \gamma -ray source FL8Y J1326.7–4729 is coincident with the core of the cluster , leading to speculation that hitherto unknown radio pulsars or annihilating dark matter may be present in the cluster core . Here we report on the discovery of five millisecond pulsars in Omega Centauri following observations with the Parkes radio telescope . Four of these pulsars are isolated with spin periods of 4.1 , 4.2 , 4.6 and 6.8 ms . The fifth has a spin period of 4.8 ms and is in an eclipsing binary system with an orbital period of 2.1 hours . Deep radio continuum images of the cluster centre with the Australian Telescope Compact Array reveal a small population of compact radio sources making it likely that other pulsars await discovery . We consider it highly likely that the millisecond pulsars are the source of the \gamma -ray emission . The long-term timing of these pulsars opens up opportunities to explore the dynamics and interstellar medium of the cluster .