The scope of the project ‘ ‘ A PSF-based Approach to TESS High Quality data Of Stellar clusters ’ ’ ( PATHOS ) is the extraction and analysis of high-precision light curves of stars in stellar clusters and young associations for the identification of candidate exoplanets and variable stars . The cutting-edge tools used in this project allow us to measure the real flux of stars in dense fields , minimising the effects due to contamination by neighbour sources . We extracted about 200 000 light curves of stars in 645 open clusters located in the southern ecliptic hemisphere and observed by TESS during the first year of its mission . We searched for transiting signals and we found 33 objects of interest , 11 of them are strong candidate exoplanets . Because of the limited S/N , we did not find any Earth or super-Earth . We identified two Neptune-size planets orbiting stars with R _ { \star } < 1.5 R _ { \sun } , implying a frequency f _ { \star } = 1.34 \pm 0.95 \% , consistent with the frequency around field stars . The 7 Jupiter candidates around stars with R _ { \star } < 1.5 R _ { \sun } imply a frequency f _ { \star } = 0.19 \pm 0.07 \% , smaller than in the field . A more complete estimate of the survey completeness and false positive rate is needed to confirm these results . Light curves used in this work will be made available to the astronomical community on the Mikulski Archive for Space Telescope under the project PATHOS .