We have computed line emission cooling rates for the main cooling species in models of interstellar molecular clouds . The models are based on numerical simulations of super–sonic magneto–hydrodynamic ( MHD ) turbulence . Non-LTE radiative transfer calculations have been performed to properly account for the complex density and velocity structures in the MHD simulations . Three models are used . Two of the models are based on MHD simulations with different magnetic field strength ( one model is super–Alfvénic , while the other has equipartition of magnetic and kinetic energy ) . The third model includes the computation of self-gravity ( in the super–Alfvénic regime of turbulence ) . The density and velocity fields in the simulations are determined self–consistently by the dynamics of super–sonic turbulence . The models are intended to represent molecular clouds with linear size L \approx 6 pc and mean density \langle n \rangle \approx 300 cm ^ { -3 } , with the density exceeding 10 ^ { 4 } cm ^ { -3 } in the densest cores . We present ^ { 12 } CO , ^ { 13 } CO , C ^ { 18 } O , O _ { 2 } , O I , C I and H _ { 2 } O cooling rates in isothermal clouds with kinetic temperatures 10–80 K. Analytical approximations are derived for the cooling rates . The inhomogeneity of the models reduces photon trapping and enhances the cooling in the densest parts of the clouds . Compared with earlier models the cooling rates are less affected by optical depth effects . The main effects come , however , from the density variation since cooling efficiency increases with density . This is very important for the cooling of the clouds as a whole since most cooling is provided by gas with density above the average .