We report the results of the XMM-Newton observation of the Pulsar Wind Nebula ( PWN ) in the composite supernova remnant G0.9+0.1 located in the Galactic Center region . Thanks to the sensitivity of the EPIC cameras , we focus on the first spectral analysis of large and small-scale structures of this PWN using MOS and PN data in combination . Our spatially resolved spectral analysis at large-scale offers a clear indication of a softening of the photon index with distance from the centroid of the nebula ( from \Gamma _ { core } =1.12 ^ { +0.45 } _ { -0.48 } to \Gamma =2.42 ^ { +0.19 } _ { -0.19 } ) , as observed in other known X-ray plerions . A spectral analysis of the small-scale structures in the central region of this PWN , delineates variations of the spectral index within the arc-like feature observed with Chandra : the eastern part has a hard photon index ( \Gamma \sim 1.2 \pm 0.5 ) , while the south-west part has a softer photon index ( \Gamma \sim 2.8 \pm 0.7 ) .