Context : Aims : We present a high quality multiwavelength ( from 0.3 to 8.0 \mu m ) catalog of the large and deep area in the GOODS Southern Field covered by the deep near–IR observations obtained with the ESO VLT . Methods : The catalog is entirely based on public data : in our analysis , we have included the F 435 W , F 606 W , F 775 W and F 850 LP ACS images , the JHKs VLT data , the Spitzer data provided by IRAC instrument ( 3.6 , 4.5 , 5.8 and 8.0 \mu m ) , and publicly available U–band data from the 2.2ESO and VLT-VIMOS . We describe in detail the procedures adopted to obtain this multiwavelength catalog . In particular , we developed a specific software for the accurate “ PSF–matching ” of space and ground-based images of different resolution and depth ( ConvPhot ) , of which we analyse performances and limitations . We have included both z –selected , as well as Ks –selected objects , yielding a unique , self–consistent catalog . The largest fraction of the sample is 90 % complete at z \simeq 26 or Ks \simeq 23.8 ( AB scale ) . Finally , we cross-correlated our data with all the spectroscopic catalogs available to date , assigning a spectroscopic redshift to more than 1000 sources . Results : The final catalog is made up of 14847 objects , at least 72 of which are known stars , 68 are AGNs , and 928 galaxies with spectroscopic redshift ( 668 galaxies with reliable redshift determination ) . We applied our photometric redshift code to this data set , and the comparison with the spectroscopic sample shows that the quality of the resulting photometric redshifts is excellent , with an average scatter of only 0.06 . The full catalog , which we named GOODS-MUSIC ( MUltiwavelength Southern Infrared Catalog ) , including the spectroscopic information , is made publicly available , together with the software specifically designed to this end . Conclusions :