A thought experiment is proposed to unify quantum mechanics and general relativity . The central paradigm is that space-time topology is ultimately responsible for the Heisenberg uncertaintly principle and the equivalence of inertial and gravitational mass . It is found that Plankian space-time exhibits a complicated , but also definite , multiply connected character . In this framework , an analysis of the interactions in Nature is presented . I . The Universal ground state of the constructed theory derives from the properties of the topological manifold Q = 2 T ^ { 3 } \oplus 3 S ^ { 1 } \times S ^ { 2 } , which has 23 intrinsic degrees of freedom , discrete Z _ { 3 } and Z _ { 2 } \times Z _ { 3 } internal groups , an SU ( 5 ) gauge group , and leads to a U ( 1 ) symmetry on a lattice . The structure of Q provides a unique equation motion for the mass-energy and particle rest mass wave functions . In its excited state the Universe is characterized by a lattice of three-tori , L ( T ^ { 3 } ) . The topological identifications present in this structure , a direct reflection of the Heisenberg uncertainty principle , provide the boundary conditions for solutions to the equation of motion , and suggest an interpretation for the conceptually difficult concept of quantum mechanical entanglement . II . In the second half of the paper the ( observable ) properties of Q and L ( T ^ { 3 } ) are investigated . One reproduces the standard model , and the theory naturally contains a Higgs field with possible inflation . The thermodynamic properties of Q yield a consistent amplitude for the cosmic microwave background fluctuations , and the manifold Q possesses internal energy scales which are independent of the field theory defined on it , but which fix the predicted mass hierarchy of such theories . The electron and its neutrino are identified as particle ground states and their masses , together with those of all other known particles , are predicted . A mass of m _ { H } = 131.6 GeV is found for the Higgs boson . Furthermore , observational diagnostics are constructed which reflect the underlying topology of Planckian space-time , and which are directly related to phenomena on much larger scales . Specific predictions are made for the coupling constants , quark confinement , black hole states , and the cosmological constant . The latter is found to be almost zero . A heuristic argument for the occurrence and magnitude of CP violation is given . III . Finally , a discrete spectral signature is predicted at integer and inverse integer multiples of the zero point frequency \nu _ { 0 } = 857.3588 MHz ( 34.96698 cm ) . That is , each photon of frequency \nu _ { 0 } m , for an integer m , is paired with an otherwise identical photon \nu _ { 0 } / m , produced by the vacuum , but not vice versa . The discrete features \nu _ { 0 } m ( and \nu _ { 0 } / m ) always have a width of 7 ^ { -3 } \nu _ { 0 } ( and 7 ^ { -3 } \nu _ { 0 } / m ^ { 2 } ) , and should provide a direct test of the reality of Q and L ( T ^ { 3 } ) independent of any standard model physics .